Site-directed mutagenesis modified glycoprotein hormones and...

Details Site-directed mutagenesis modified glycoprotein hormones and... Site-directed mutagenesis modified glycoprotein hormones and...

C - Chemistry, Metallurgy

07

K

530/15.14, 530/7

C07K 14/59 (2006.01) A61K 38/24 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1341284

Described are new glycoprotein hormones capable of competing with natural hormones for the normal receptor binding sites but substantially incapable of effecting post receptor activities. The glycoprotein hormones of the present invention have had specific (rather than all) oligosaccharide chains removed so as to effectively diminish biologic activity while not significantly reducing plasma half-life, thus improving the molecules effectiveness as an antagonist compared with conventionally produced molecules. The preferred glycoprotein hormones are ideally obtained by site-directed mutagenesis to selectively deglycosylate the protein. Also described are therapeutic treatments comprising the administration of the recombinant glycoprotein hormones of the present invention as hormone antagonists.

585309

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