Site selective plasminogen activator and method of making...

Details Site selective plasminogen activator and method of making... Site selective plasminogen activator and method of making...

A - Human Necessities

61

K

195/1.1

A61K 39/395 (2006.01) A61K 37/54 (1985.01)

Patent

CA 1244361

ABSTRACT OF THE DISCLOSURE A method of making an activator and the resulting thera- peutic product suitable for lysing fibrin in site-selective action in an animal species identified by a target protein selected from fibrin and cardiac myosin. An animal of a second species is immunized with the target protein, and myeloma cells of the species are fused with spleen cells from the thus immunized second species to provide antibody producing immortal hybrid cells. The hybrid cells are cloned, and those of the hybrid cells that produce antibody that is specific to said target protein and non-specific to fibrinogen are selected and subcloned in a culture medium. The thus produced antibody is isolated and coupled with an enzyme selected from the group consisting of urokinase and streptokinase.

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