C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
167/119, 195/1.2
C07F 15/06 (2006.01) A61K 31/555 (2006.01) C07F 15/00 (2006.01) C07H 21/02 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 1339360
This invention concerns a coordination complex of the formula (R)2---M---(Y)2 wherein M comprises a suitable transition metal, e.g. cobalt or ruthenium, R comprises 1,10-phenanthroline or a substituted derivative thereof, Y comprises a labile ligand, e.g. chloride, tartrate, malonate or ascorbate ion and R and Y are bonded to M by coordination bonds. A complex of this invention may be used for covalently labeling DNA with a complex of the formula (R)2---M, wherein R and M are as previously defined. A complex of this invention which contains cobalt may also be used in a method for nicking DNA by effecting single-stranded scission of at least one phosphodiester bond of the DNA with ultraviolet radiation. A complex of this invention is further useful in a method for killing tumor cells. A pharmaceutical composition for the treatment of tumor cells in a subject may be prepared containing an effective anti-tumor amount of a complex of this invention and a pharmaceutically acceptable carrier. Such a composition may be used for treating a subject afflicted with tumor cells so as to cause regression of the tumor cells.
499792
Gowling Lafleur Henderson Llp
The Trustees Of Columbia University In The City Of New York
LandOfFree
Site-specific chiral ruthenium (ii) and cobalt (iii)... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Site-specific chiral ruthenium (ii) and cobalt (iii)..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Site-specific chiral ruthenium (ii) and cobalt (iii)... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1297516