Site-specific conjugation of immunoglobulins and detectable...

Details Site-specific conjugation of immunoglobulins and detectable... Site-specific conjugation of immunoglobulins and detectable...

G - Physics

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G01N 33/532 (2006.01) A61K 39/395 (2006.01) C07K 1/107 (2006.01) C07K 1/113 (2006.01) C07K 16/00 (2006.01) C07K 16/06 (2006.01) C12P 21/08 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2097920

A process for producing a derivatized immunoglobulin and conjugates prepared therewith are provided. The derivatized immunoglobulin is produced by introducing sulfhydryl groups in the Fc region of an immunoglobulin wherein the Fab portion of the immunoglobulin is not altered. The derivatized immunoglabulin is used to prepare conjugates with various detectable moie- ties wherein a controlled distance exists between the Fc region of the immunoglobulin and the detectable moiety. The conjugates are particularly useful for performing immunoassays, and exhibit improved longevity, specificity and sensitivity.

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