Site-specific, covalent bioconjugation of proteins

Details Site-specific, covalent bioconjugation of proteins Site-specific, covalent bioconjugation of proteins

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) A61K 47/48 (2006.01) C07K 1/113 (2006.01) C08H 1/00 (2006.01) C09D 189/00 (2006.01) G01N 33/50 (2006.01) G01N 33/52 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2404082

Heterofunctional crosslinking groups are provided having the formula (I) wherein W is a covalent core component; L1, L2 and L3 are independently linking groups; X is a non-covalent or reversibly covalent protein tag binder; Y is a activatable covalent linking group; and Z is a protected or unprotected covalent crosslinking group.

L'invention concerne des groupes de réticulation hétérofonctionnels de formule (I) dans laquelle W est un élément de noyau covalent; L?1¿, L?2¿ et L?3¿ représentent des groupes de liaison indépendants les uns des autres; X représente un marqueur de protéine inversement covalent ou non-covalent; Y représente un groupe de liaison covalente activable; et Z représente un groupe de réticulation covalente protégée ou non-protégée.

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