Site-specific immunization in order to establish antibodies...

Details Site-specific immunization in order to establish antibodies... Site-specific immunization in order to establish antibodies...

C - Chemistry, Metallurgy

07

K

C07K 16/08 (2006.01) A61K 39/12 (2006.01) C12N 7/01 (2006.01)

Patent

CA 2596621

The present invention relates to a method for establishment of antibodies with specificity for high-risk HPVs compared to immunization using the whole antigen of high-risk HPVs, wherein the method includes an exclusion of evolutionary conserved motifs as well as regions with high similarity to E7 proteins of low-risk HPVs, as well as thus obtained antibodies.

La présente invention concerne une méthode pour l'établissement d'anticorps présentant une spécificité pour les HPV à haut risque comparé à l'immunisation à l'aide de l'antigène entier de HPV à haut risque, la méthode faisant appel à l'exclusion de motifs conservés évolutifs ainsi que de régions présentant une similarité élevée avec des protéines E7 d'HPV à haut risque, ainsi que des anticorps ainsi obtenus.

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