C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/10 (2006.01) C12P 21/00 (2006.01) C12N 9/00 (2006.01) C12N 15/52 (2006.01) C12N 15/85 (2006.01) C12N 5/06 (2006.01)
Patent
CA 2662752
This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in vertebrate cells. The components include orthogonal tRNA's, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNA's/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in vertebrate cells are also provided.
L'invention concerne des compositions et des méthodes de production de composants de traduction qui augmentent le nombre d'acides aminés génétiquement codés dans des cellules de vertébrés. Parmi les composants, on trouve des ARNt, des aminoacyl-ARNt synthétases orthogonales, des aminoacyl-ARNt synthétases orthogonales, des paires orthogonales d'ARNt/synthétases et des acides aminés non naturels. L'invention concerne également des protéines et des méthodes de production de protéines à acides aminés non naturels dans des cellules de vertébrés.
Chu Stephanie
Norman Thea
Tian Feng
Ambrx Inc.
Smart & Biggar
LandOfFree
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