Site-specific isotopically-labeled proteins, amino acids,...

C - Chemistry – Metallurgy – 07 – B

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C07B 59/00 (2006.01) C07C 59/185 (2006.01) C07C 229/08 (2006.01) C07K 1/107 (2006.01) C07K 1/13 (2006.01) C12N 9/64 (2006.01) C12P 13/04 (2006.01) C12P 13/06 (2006.01) C12P 13/08 (2006.01) C12P 21/00 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2368652

Site-specific isotopically-labeled valine, leucine, and isoleucine and biosynthetic precursors for these amino acids are provided. The amino acids are labeled with 13C or 14C at the methyl group carbon atom(s) most remote from the carboxyl group. Also disclosed are the biochemical precursors of these labeled amino acids, 2-keto-4-(n C)butyric acid and 2-keto-3-(n C-methyl)-4-(n C)-butyric acid in which n, at each occurrence, is 13 or 14. Also disclosed are proteins, protein fragments, and polypeptides containing these site-specifically isotopically labeled amino acids, and methods for preparing the biochemical precursors, the amino acids, and the proteins, protein fragments, and polypeptides.

L'invention concerne une valine, une leucine et une isoleucine, isotopiquement marquées, spécifiques de sites, ainsi que des précurseurs biosynthétiques de ces acides aminés. On a marqué ces acides aminés à l'aide de <13>C ou de <14>C, au niveau de (des) atome(s) de carbone du groupe méthyle qui est (sont) le(s) plus éloigné(s) du groupe carboxyle. L'invention concerne également des précurseurs biochimiques de ces acides aminés marqués, l'acide 2-céto-4-(<n>C)butyrique et l'acide 2-céto-3-(<n>C-méthyl)-4-(<n>C)-butyrique, dans lesquels n représente à chaque fois 13 ou 14. L'invention concerne également des protéines, des fragments de protéines, ainsi que des polypeptides contenant ces acides aminés isotopiquement marqués, spécifiquement pour un site, ainsi que des procédés de préparation des précurseurs biochimiques, acides aminés, protéines, fragments de protéines et polypeptides.

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