Site specific mutagenesis in alpha-1-antitrypsin

Details Site specific mutagenesis in alpha-1-antitrypsin Site specific mutagenesis in alpha-1-antitrypsin

C - Chemistry, Metallurgy

12

N

530/13, 195/1.22

C12N 15/15 (2006.01) C07K 14/81 (2006.01) C12N 1/16 (2006.01) C12N 1/20 (2006.01) C12N 15/10 (2006.01) C12N 15/63 (2006.01) C12N 15/70 (2006.01) C12N 15/81 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1341219

Methods are provided for producing sites specific mutagenized alpha-1-antitrypsin. Particular mutants are formed having a mutation in the active site of alpha-1- antitrypsin at amino acid position 358 and at amino acid position 342.

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