C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/10 (2006.01) C07K 14/01 (2006.01) C12N 15/31 (2006.01) C40B 40/08 (2006.01) C40B 50/06 (2006.01)
Patent
CA 2575533
This invention relates to the diversification of nucleic acid sequences by use of a nucleic acid molecule containing a region of sequence that acts as a template for diversification. The invention thus provides nucleic acid molecules to be diversified, as well as those which act as the template region (TR) and in concert with the TR for directional, site-specific diversification. Further provided are methods of preparing and using these nucleic acid sequences.
L'invention se rapporte à la diversification de séquences d'acide nucléique au moyen d'une molécule d'acide nucléique comportant une région de séquence qui sert de matrice pour la diversification. Cette invention concerne également des molécules d'acide nucléique à diversifier, ainsi que des molécules d'acide nucléique servant de région matricielle (TR) et agissant de concert avec la TR pour une diversification directionnelle à spécificité de site. Cette invention se rapporte en outre à des procédés de préparation et d'utilisation de ces séquences d'acide nucléique.
Doulatov Sergei
Gingery Mari
Hodes Asher
Martin David W. Jr.
Miller Jeffery F.
Avidbiotics Corporation
Smart & Biggar
The Regents Of The University Of California
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