Six membered amino-amide derivatives as angiogenesis inhibitors

C - Chemistry – Metallurgy – 07 – D

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C07D 213/46 (2006.01) A61K 31/44 (2006.01) C07D 213/53 (2006.01)

Patent

CA 2568608

The present invention relates to six membered amino-amide derivatives, processes for their preparation, pharmaceutical compositions containing them as active ingredient, methods for the treatment of disease states associated with angiogenesis and/or increased vascular permeability, to their use as medicaments and to their use in the manufacture of medicaments for use in the production of antiangiogenic and/or vascular permeability reducing effects in warm-blooded animals such as humans.

La présente invention se rapporte à des dérivés amino-amide à six éléments, à leurs procédés de préparation, aux compositions pharmaceutiques les contenant comme principe actif, aux méthodes de traitement d'états pathologiques associés à l'angiogenèse et/ou à la perméabilité vasculaire accrue, à leur utilisation comme médicaments et à leur utilisation dans la fabrication de médicaments visant à produire des effets antiangiogéniques et/ou de réduction de la perméabilité vasculaire chez les animaux à sang chaud, notamment les humains.

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