C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/077 (2010.01) A61K 35/34 (2006.01) A61K 38/18 (2006.01) A61P 9/10 (2006.01) C12Q 1/02 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2545198
The disclosure provides methods of propagating skeletal muscle cell (SkMC) cultures enriched in differentiation-competent myoblasts that express normal levels of CD56 and reduced levels of desmin. The methods comprise culturing SkMCs in a mitogen-rich cell culture medium supplemented with TGF-.beta.. The disclosure also provides therapeutic methods utilizing SkMCs propagated in TGF- .beta., e.g., methods of treating myocardial infarction by transplantation of autologous or allogeneic SkMCs.
L'invention concerne des procédés de propagation de cultures de cellules du muscle squelettique (SkMC) enrichies en myoblastes à capacité de différenciation qui expriment des niveaux normaux de CD56 et des niveaux réduits de desmine. Les procédés consistent à cultiver des SkMC dans un milieu de culture cellulaire riche en mitogène complété de TGF-.beta.. Cette invention concerne également des procédés thérapeutiques utilisant des SkMC propagés dans du TGF-.beta., par exemple, des procédés de traitement de l'infarctus du myocarde par transplantation de la SkMC autologue ou allogénique.
Stewart Jeffrey D.
Wentworth Bruce M.
Yaeger Peter C.
Genzyme Corporation
Gowling Lafleur Henderson Llp
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