Skeletally targeted nanoparticles

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/51 (2006.01) A61P 19/08 (2006.01) A61P 19/10 (2006.01)

Patent

CA 2536246

The invention provides methods and compositions for the delivery of bioactive factors to the systemic skeleton. The methods of the invention allow targeted delivery of bioactive factors to bone using nanocapsules comprised of amphipathic materials. Timed release of bioactive factors may also be used to increase the efficacy of treatment. The methods of the invention have wide applicability for the treatment or prevention of bone-associated maladies.

L'invention concerne des procédés et des compositions destinées à diriger des facteurs bioactifs sur le squelette systémique. Les procédés de l'invention permettent l'administration de facteurs bioactifs ciblant les os, qui utilise des nanocapsules constituées de matières amphipathiques. La libération de facteurs bioactifs contrôlée dans le temps peut aussi servir à augmenter l'efficacité d'un traitement, et les procédés de l'invention trouvent de nombreuses applications dans le traitement ou la prévention de maladies osseuses.

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