Skin and muscle-targeted gene therapy by pulsed electrical...

A - Human Necessities – 61 – N

Patent

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A61N 1/30 (2006.01) A61M 37/00 (2006.01) A61N 1/32 (2006.01)

Patent

CA 2337652

The present invention describes an in vivo method, using pulsed electric field to deliver therapeutic agents into cells of the skin and muscle for local and systemic treatments. In particular, therapeutic agents include naked or formulated nucleic acid, polypeptides and chemotherapeutic agents.

On décrit un procédé in vivo dans lequel on utilise un champ électrique pulsé pour apporter des agents thérapeutiques dans des cellules de la peau et des muscles pour effectuer des traitements locaux et systémiques. Les agents thérapeutiques comprennent plus particulièrement l'acide nucléique pur ou formulé, des polypeptides et des agents chimiothérapeutiques.

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