A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 8/67 (2006.01)
Patent
CA 2265635
Compounds which sufficiently inhibit LRAT or ARAT catalyzed esterification of retinol into inactive retinyl esters, have the same effect on keratinocytes as retinoic acid. Thus, effects of retinol or retinyl esters in combination with these compounds are analogous to treatment with retinoic acid.
L'invention concerne des composés qui inhibent suffisamment l'estérification du rétinol catalysée par une acyl-CoA rétinol transférase (ARAT) ou une lécithine rétinol acyle transférase (LRAT) dans des esters de rétinyle inactifs. Ces composés exercent le même effet sur les kératinocytes que l'acide rétinoïque. Ainsi, les effets du rétinol ou des esters de rétinyle en association avec ces composés sont semblables au traitement par l'acide rétinoïque.
Burger Allan Robert
Granger Stewart Paton
Iwata Koichi
Rawlings Anthony Vincent
Scott Ian Richard
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Plc Unilever
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