Skin permeation enhancer compositions

A - Human Necessities – 61 – K

Patent

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167/159

A61K 47/10 (2006.01) A61K 9/70 (2006.01) A61K 31/56 (2006.01) A61K 47/14 (2006.01)

Patent

CA 2012875

Skin permeation enhancer compositions are provided which increase the permeability of skin to transdermally administered pharmacologically active agents. The composition contains diethylene glycol monoethyl or monomethyl ether in addition to an ester component such as propylene glycol monolaurate, methyl laurate or the like. The compositions are particularly useful in conjunction with the transdermal administration of steroid drugs such as progestogens and estrogens. Methods and drug delivery systems for using the enhancer compositions are provided as well.

Compositions améliorant la perméation de la peau, lesquelles augmentent la perméabilité de la peau aux agents pharmacologiquement actifs, administrés par voie dermique. La composition renferme un éther monoéthylique ou monométhylique de diéthylèneglycol en plus d'un ester, comme un monolaurate de propylèneglycol, un laurate de méthyle ou un produit analogue. Ces compositions sont particulièrement utiles, lorsqu'elles sont utilisées conjointement avec l'administration transdermique de médicaments steroïdiens, comme les progestinogènes et les oestrogènes. L'invention présente également des méthodes et des systèmes d'administration de médicaments utilisant ces compositions.

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