Skin permeation enhancer compositions using acyl lactylates

Details Skin permeation enhancer compositions using acyl lactylates Skin permeation enhancer compositions using acyl lactylates

A - Human Necessities

61

K

A61K 47/14 (2006.01) A61K 9/70 (2006.01) A61K 31/565 (2006.01) A61K 31/57 (2006.01) A61K 47/16 (2006.01) A61M 37/00 (2006.01)

Patent

CA 2217029

The present invention is directed to the transdermal administration of a drug together with a suitable amount of an acyl lactylate permeation enhancer. The invention includes a transdermal drug delivery device comprising a matrix adapted to be placed in drug-and permeation enhancer-transmitting relation with a skin site. The matrix contains sufficient amounts of an acyl lactylate permeation enhancer and drug, in combination, to continuously administer drug to the systemic circulation of a patient at a therapeutically effective rate. The invention is also directed to compositions and methods for transdermal administration of a drug together with an acyl lactylate permeation enhancer, alone or in combination with other enhancers.

La présente invention concerne l'administration percutanée d'un médicament en association avec une quantité appropriée d'acyl-lactylate augmentant la perméabilité de la peau. L'invention concerne un dispositif d'administration d'un composé par voie percutanée comprenant une matrice destinée à être placée sur le corps de manière à permettre la diffusion vers la peau de l'acyl-lactylate et du médicament. La matrice contient une quantité suffisante de l'acyl-lactylate et de médicament, pour assurer une administration continue de ce médicament vers le système circulatoire systémique d'un patient, à une vitesse suffisante pour obtenir l'effet thérapeutique souhaité. L'invention concerne également des compositions et des procédés d'administration percutanée d'un médicament en présence de l'acyl-lactylate seul ou combiné à d'autres agents capables d'augmenter la perméabilité de la peau.

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