A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/30 (2006.01) A61K 38/07 (2006.01) A61K 38/08 (2006.01) A61K 38/18 (2006.01) A61P 17/02 (2006.01)
Patent
CA 2418976
The present invention provides healing promoters for skin wounds such as rupture, abrasion, surgical incision, skin ulcer and burn. Coexistence of Arg-Pro-Lys -Pro -Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 or Phe-Gly-Leu-Met-NH2 with insulin-like growth factor-I exhibits a remarkable promotive action on healing the skin wounds. Accordingly, combined administration of at least one of the substance P analogs and pharmaceutically acceptable salts thereof with the insulin-like growth factor exhibits a promotive effect on epidermal extension and a promotive effect on healing the skin wounds.
L'invention concerne des promoteurs de cicatrisation des lésions cutanées telles que les déchirures, les écorchures, les incisions chirurgicales, les ulcères cutanés et les brûlures. La coexistence d'Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH¿2 ?ou de Phe-Gly-Leu-Met-NH¿2? et du facteur I de croissance semblable à l'insuline favorise remarquablement la cicatrisation des lésions cutanées. En particulier, l'administration d'une combinaison d'au moins un élément sélectionné parmi les analogues de la substance P et les sels acceptables d'un point de vue pharmaceutique de ceux-ci et du facteur de croissance semblable à l'insuline favorise l'extension épidermique de la peau et la cicatrisation des lésions.
Nakamura Masatsugu
Nakata Katsuhiko
Nishida Teruo
Fetherstonhaugh & Co.
Nishida Teruo
Santen Pharmaceutical Co. Ltd.
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