C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07K 14/72 (2006.01) C07K 16/28 (2006.01) C07K 19/00 (2006.01) C12N 15/11 (2006.01) C12N 15/62 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/566 (2006.01)
Patent
CA 2344457
The invention provides isolated nucleic acids molecules, designated SLGP nucleic acid molecules, which encode GPCR family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing SLGP nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an SLGP gene has been introduced or disrupted. The invention still further provides isolated SLGP proteins, fusion proteins, antigenic peptides and anti-SLGP antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
L'invention concerne des molécules d'acide nucléique isolées, appelées molécules d'acide nucléique SLGP, qui codent pour des membres de la famille GPCR (G-Protein Coupled Receptors: récepteurs couplés à la protéine G). L'invention concerne également des molécules d'acide nucléique antisens, des vecteurs d'expression recombinants contenant des molécules d'acide nucléique SLGP, des cellules hôtes dans lesquelles les vecteurs d'expression ont été introduits et des animaux transgéniques dans lesquels un gène SLGP a été introduit ou disloqué. L'invention concerne en outre des protéines SLGP isolées, des protéines de fusion, des peptides antigéniques et des anticorps anti-SLGP. Enfin l'invention concerne des méthodes de diagnostic utilisant les compositions décrites.
Borden Ladner Gervais Llp
Millennium Pharmaceuticals Inc.
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