C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/10 (2006.01) C07K 14/705 (2006.01) C12N 15/12 (2006.01) C12N 15/63 (2006.01)
Patent
CA 2428350
The invention provides isolated nucleic acid and amino acid sequences of Slo2 and Slo4, members of the Slo family of potassium channel proteins, also known as "maxi" or BK potassium channel proteins. Also provided herein are antibodies to Slo2 and Slo 4, methods of detecting Slo2 and Slo 4, methods of screening for potassium channel activators and inhibitors using biologically active Slo2 and Slo 4, and kits for screening for activators and inhibitors of voltage-gated potassium channels comprising Slo2 and Slo 4.
L'invention concerne des séquences isolées d'acide nucléique et d'acide aminé de Slo2 et Slo4, membres de la famille Slo des protéines de canal potassique, également appelées protéines <= maxi >= ou protéines BK de canal potassique. L'invention concerne également des anticorps de Slo2 et Slo4, des méthodes de détection de Slo2 et Slo 4, des méthodes de criblage d'activateurs et d'inhibiteurs de canal potassique mettant en oeuvre des protéines Slo2 et Slo4 biologiquement actives, et un matériel de criblage d'activateurs et d'inhibiteurs de canaux potassiques sensibles au voltage comprenant Slo2 et Slo 4.
Jegla Timothy James
Witzel Julie Dickson
Fetherstonhaugh & Co.
Icagen Inc.
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