Slow-onset, long-lasting dopamine reuptake blockers

Details Slow-onset, long-lasting dopamine reuptake blockers Slow-onset, long-lasting dopamine reuptake blockers

C - Chemistry, Metallurgy

07

C

C07C 211/42 (2006.01) A61K 31/135 (2006.01) A61K 31/275 (2006.01) A61K 31/33 (2006.01) C07C 211/49 (2006.01) C07C 215/64 (2006.01) C07C 217/74 (2006.01) C07C 255/58 (2006.01) C07D 209/52 (2006.01) C07D 221/04 (2006.01) C07D 307/93 (2006.01) C07D 333/78 (2006.01)

Patent

CA 2263489

Disclosed is a method of treating an individual who abuses cocaine by administering to the individual a therapeutically effective amount of an N,N- dialkyl 3-phenyl-1-indamine or a mixture of N,N-dialkyl 3-phenyl-1-indamines. Also disclosed is a method of treating an individual with Parkinson's disease or an individual with attention deficit hyperactivity disorder by administering to the individual a therapeutically effective amount of an N,N- dialkyl 3-phenyl-1-indamine or a mixture of N,N-dialkyl 3-phenyl-1-indamines. Also disclosed are novel N,N-dialkyl 3-phenyl-1-indamines and N-(tert-butyl) 3- phenyl-1-indamines.

La présente invention décrit un procédé de traitement d'un individu souffrant d'un abus de cocaïne en lui administrant une dose thérapeutiquement efficace de N,N-dialkyl 3-phényl-1-indamine ou d'un mélange de N,N-dialkyl 3-phényl-1-indamine. L'invention décrit aussi un procédé de traitement d'un individu souffrant de la maladie de Parkinson ou d'un individu souffrant de désordres d'hyperactivité déficitaire d'attention en administrant audit individu une dose thérapeutiquement efficace de N,N-dialkyl 3-phényl-1-indamine ou un mélange de N,N-dialkyl 3-phényl-1-indamines. Enfin, l'invention décrit de nouveaux mélanges de N,N-dialkyl 3-phényl-1-indamine ou de N-(tert-butyle) 3-phényl-1-indamines.

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