Slow release formulation of clarithromycin

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/22 (2006.01) A61K 9/20 (2006.01) A61K 31/7048 (2006.01) A61K 9/28 (2006.01)

Patent

CA 2505599

The invention relates to an orally administrable pharmaceutical composition comprising an alginate matrix consisting of a water-soluble alginate salt and a complex salt of alginic acid, a macrolide, and an inorganic salt characterized in that the inorganic salt is capable of donating a proton and has a pKa value in water of 4.0 to 9Ø

L'invention concerne une composition pharmaceutique administrable par voie orale, comprenant une matrice d'alginate constituée d'un sel alginate hydrosoluble et d'un sel complexe d'acide alginique, d'un macrolide et d'un sel inorganique caractérisé en ce qu'il est capable de donner un proton et qu'il présente une valeur pK¿a? dans l'eau comprise entre 4,0 et 9,0.

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