Slow release syneresing polymeric drug delivery device

Details Slow release syneresing polymeric drug delivery device Slow release syneresing polymeric drug delivery device

A - Human Necessities

01

N

A01N 25/10 (2006.01) A01N 25/34 (2006.01) A01N 43/16 (2006.01) A61K 9/20 (2006.01) A61K 31/35 (2006.01) A61K 47/30 (2006.01)

Patent

CA 2080574

105/DLR55 18352 TITLE OF THE INVENTION SLOW RELEASE SYNERESING POLYMERIC DRUG DELIVERY DEVICE ABSTRACT OF THE DISCLOSURE There is disclosed a slow release drug delivery device for the prolonged administration of topically active medicines which consists of a vehicle in which water is soluble and in which is dissolved the topically active drug which is formed into a stable organogel with a polymer matrix with a very low water absorbing capability. The organogel, in the presence of water or atmospheric water vapor, slowly imbibes such water into the vehicle and by doing so the vehicle becomes incompatible with the matrix and is slowly expelled therefrom. The vehicle dissolves the drug and the vehicle/drug combination is slowly pumped out of the polymeric matrix with substantially linear drug delivery occurring for periods in excess of 6 months. The drug delivery device may be used to administer drugs topically, as a collar or trans dermal patch, orally, as a slow delivery device, particularly as a ruminal bolus,, or as a suppository or a subcutaneous implant. The preferred form for the drug delivery device is as a flea and tick collar for household pets and the preferred active drug is selected from the avermectin and milbemycin families of active antiparasitic agents.

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