Smac mimetic dimers and trimers useful as anti-cancer agents

Details Smac mimetic dimers and trimers useful as anti-cancer agents Smac mimetic dimers and trimers useful as anti-cancer agents

C - Chemistry, Metallurgy

07

D

C07D 207/16 (2006.01) A61K 31/4025 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07D 249/04 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 487/14 (2006.01)

Patent

CA 2684169

The invention provides small molecule mimics of the SMAC peptide that are dimer-like or trimer-like compounds having two or three amide-containing domains connected by a linker. These compounds are useful to promote apoptosis. The invention includes pharmaceutical compositions comprising such compounds and methods to use them to treat conditions including cancer and autoimmune disorders.

L'invention concerne des mimétiques de petites molécules du peptide SMAC qui sont des composés de type dimère ou de type trimère ayant deux ou trois domaines contenant un amide reliés par un lieur. Ces composés sont utiles pour favoriser l'apoptose. L'invention comprend des compositions pharmaceutiques comprenant de tels composés et des procédés pour les utiliser dans le but de traiter des affections comprenant le cancer et les maladies auto-immunes.

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