Small animal model for hcv replication

Details Small animal model for hcv replication Small animal model for hcv replication

A - Human Necessities

01

K

A01K 67/00 (2006.01) C12N 5/06 (2006.01)

Patent

CA 2615626

An animal model for HCV replication and/or production of virus or virus like particles is provided. The invention utilizes an HCV replicon present in a cell to deliver HCV nucleic acid and replicate and express HCV proteins in an animal model comprising an animal that has been immunocompromised. The invention further provides a method of treatment or prevention of HCV in a mammal which comprises administering to the mammal a combination which comprises an immunomodulatory compound and another antiviral agent. Also provided are cell lines showing a decreased sensitivity to interferon alpha or some other immunomodulator and methods of making or isolating such cell lines.

L'invention concerne un modèle animal pour une réplication HCV et/ou une production de virus ou de particules de type virus. L'invention concerne un réplicon HCV présent dans une cellule pour délivrer un acide nucléique HCV et répliquer et exprimer des protéines HCV dans un modèle animal comportant un animal immunocompromis. L'invention concerne également un procédé de traitement ou de prévention de HCV chez un mammifère consistant à administer au mammifère une association qui contient un composé immunomodulateur et autre agent antiviral. L'invention concerne également des lignées cellulaires ayant une sensibilité réduite à l'interféron alpha ou autre immunomodulateur. L'invention concerne enfin des procédés de production ou d'isolement de telles lignées cellulaires.

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