C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/36 (2006.01) A61K 31/7088 (2006.01) A61K 38/16 (2006.01) A61K 48/00 (2006.01) A61P 29/00 (2006.01) A61P 31/04 (2006.01) A61P 37/04 (2006.01) C07K 14/195 (2006.01) C07K 14/31 (2006.01) C07K 14/315 (2006.01) C12N 15/31 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2690267
Cationic bacteriocin and lantibiotic peptides are provided and their immunomodulatory activities are described. Methods are provided for selectively enhancing innate immunity. Other methods are provided for selectively suppressing a proinflammatory response. Other methods are provided for identifying a compound or compounds which modulate an innate immune response. Pharmaceutical compositions comprising the cationic bacteriocin and lantibiotic peptides or polynucleotides are also provided.
La présente invention concerne une bactériocine cationique et des peptides lantibiotiques, ainsi que leurs activités immunomodulatrices. L'invention concerne également des procédés destinés à améliorer de manière sélective l'immunité naturelle. L'invention concerne en outre des procédés destinés à supprimer de manière sélective une réponse proinflammatoire. L'invention concerne de plus des procédés destinés à identifier un ou des composés qui modulent une réponse immunitaire naturelle. L'invention concerne également des compositions pharmaceutiques comprenant la bactériocine cationique et les peptides ou les polynucléotides lantibiotiques.
Elliott Melissa
Hancock Robert E.
Sahl Hans-Georg
Smart & Biggar
The University Of British Columbia
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