Small cyclic platelet aggregation inhibitors

Details Small cyclic platelet aggregation inhibitors Small cyclic platelet aggregation inhibitors

C - Chemistry, Metallurgy

07

K

C07K 7/06 (2006.01) A61K 38/08 (2006.01) C07K 1/06 (2006.01) C07K 14/75 (2006.01) C07K 14/78 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2063557

2063557 9101331 PCTABS00003 A platelet aggregation inhibitor useful as an antithrombotic is provided which consists of a synthetic cyclic pentapeptide containing the tripeptide sequence Arg-Gly-Asp and a thioether linkage in the cycle. A preferred platelet aggregation inhibitor is represented by formula (I), where R1 and R9 are OH; R2, R4, R5, R6, R7, R8 and R14 are hydrogen; R3 and R4 are joined to form a pyrrolidine ring; X is sulfur; m is 1 and n is 3.

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