Small diameter nanocapsules, process for their preparation...

A - Human Necessities – 61 – K

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A61K 9/51 (2006.01) A61K 6/00 (2006.01) A61K 47/32 (2006.01)

Patent

CA 2153343

Nanocapsules typically having a diameter in the range of 20-150 nm are provided and consist of a polymeric shell formed of a surface active poly(alkyl cyanoacrylate) material arranged in one or more layers. The polymeric shell can be composed of a surface active poly(alkyl 2-cyanoacrylate) having general formula (I), wherein R is -CH2?CH2?mCH3, -CH2?CH2?mCOOH, -CH2?CH2?mCOOR', or -CH2CH2-O?CH2CH2-O?mR'; R' is -CH3, -CH2?CH2?mCH3, -C?CH3?2-CH2-C(CH3)3, or -O-Ar, m has a value of from 0 to 20; and n has a value of from 1 to 20, formed by the interfacial polymerization of self-arranged micelles of the cyanoacrylate monomers. The nanocapsules can be used to encapsulate a wide range of water soluble and water insoluble active agents in high yield for delivery to a target system or locus, for example drugs for use in therapy or prophylaxis.

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