Small interfering ribonucleic acid duplexes comprising...

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A61K 48/00 (2006.01) A61K 31/713 (2006.01) A61P 31/12 (2006.01) C07H 21/02 (2006.01)

Patent

CA 2627000

Small interfering ribonucleic acid duplexes (siRNA) comprising at least one arabinose modified nucleotide that inhibit gene expression are Provided. In one embodiment, the duplexes contain ribonucleotides wherein at least one arabinose modified nucleotide is a 2'-deoxy-2'- fluoroarabinonucleotide (FANA).

L'invention concerne de petites molécules duplex d'acide ribonucléique interférent qui inhibent l'expression génique et contiennent au moins un nucléotide d'arabinose modifié. De préférence, les molécules duplex contiennent des ribonucléotides, au moins un nucléotide à arabinose modifié étant le 2'-désoxy-2'-fluoroarabinonucléotide (FANA).

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