A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61K 31/713 (2006.01) A61P 31/12 (2006.01) C07H 21/02 (2006.01)
Patent
CA 2627000
Small interfering ribonucleic acid duplexes (siRNA) comprising at least one arabinose modified nucleotide that inhibit gene expression are Provided. In one embodiment, the duplexes contain ribonucleotides wherein at least one arabinose modified nucleotide is a 2'-deoxy-2'- fluoroarabinonucleotide (FANA).
L'invention concerne de petites molécules duplex d'acide ribonucléique interférent qui inhibent l'expression génique et contiennent au moins un nucléotide d'arabinose modifié. De préférence, les molécules duplex contiennent des ribonucléotides, au moins un nucléotide à arabinose modifié étant le 2'-désoxy-2'-fluoroarabinonucléotide (FANA).
Damha Masad
Ferrari Nicolay
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Topigen Pharmaceuticals Inc.
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