Small internally segmented interfering rna

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/11 (2006.01) C12N 15/113 (2010.01) A61K 31/7088 (2006.01) A61K 31/713 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2644347

The present invention is directed to pharmaceutical and therapeutic compositions which comprise RNA complexes comprising an antisense strand and a discontinued passenger strand capable of regulating gene expression. The use of a discontinued passenger strand reduces off target effects of the RNA complexes and also has other advantages.

Cette invention concerne des compositions pharmaceutiques et thérapeutiques qui comprennent des complexes d'ARN contenant un brin antisens et un brin passager discontinu pouvant réguler l'expression génique. L'utilisation d'un brin passager discontinu permet de réduire les effets hors cible des complexes d'ARN. L'utilisation d'un brin passager discontinu présente également d'autres avantages.

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