A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/12 (2006.01) A61K 31/11 (2006.01) A61K 31/135 (2006.01) A61K 31/19 (2006.01) A61K 31/225 (2006.01) A61K 31/335 (2006.01) C12Q 1/02 (2006.01)
Patent
CA 2449245
The present invention relates to naturally occurring and chemically synthesized small molecules antagonists of Bcl-2 family proteins. In particular, the present invention provides gossypol derivatives and methods of using gossypol derivatives as antagonists of the anti-apoptotic effects of Bcl- 2 and Bcl-XL proteins especially in cancer cells that overexpress Bcl-2 family proteins (e.g., Bcl-2 and/or Bcl-XL).
La présente invention concerne des petits antagonistes moléculaires naturels et obtenus par synthèse chimique de protéines de la famille Bcl2. En particulier, la présente invention concerne des dérivés de gossypol et des méthodes d'utilisation de dérivés de gossypol en tant qu'antagonistes des effets anti-apoptotiques des protéines Bcl-2 et Bcl-X¿L?, en particulier dans ces cellules cancéreuses qui surexpriment les protéines de la famille Bcl-2 (par ex., Bcl-2 et / ou Bcl-X¿L?).
Wang Shaomeng
Yang Dajun
Georgetown University Medical Center
Sim & Mcburney
The Regents Of The University Of Michigan
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