Small molecule apoptosis promoters

Details Small molecule apoptosis promoters Small molecule apoptosis promoters

C - Chemistry, Metallurgy

07

K

C07K 5/083 (2006.01) A61K 31/4025 (2006.01) A61K 38/06 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07K 5/08 (2006.01)

Patent

CA 2646186

The invention provides small molecule mimics of the Smac peptide that are dimer- or dimer-like compounds having two amide-containing domains connected by a linker. These compounds are useful to promote apoptosis. The invention includes pharmaceutical compositions comprising such compounds and methods to use them to treat conditions including cancer and autoimmune disorders.

La présente invention concerne des mimétiques de petites molécules du peptide Smac qui sont des composés dimères ou de type dimérique comprenant deux domaines reliés par un lieur. Ces composés sont utiles pour promouvoir l'apoptose. L'invention concerne également des compositions pharmaceutiques comportant de tels composés et leurs procédés d'utilisation pour traiter des conditions pathologiques telles que le cancer et des troubles auto-immunitaires.

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