Small molecule bradykinin b1 receptor antagonists

Details Small molecule bradykinin b1 receptor antagonists Small molecule bradykinin b1 receptor antagonists

C - Chemistry, Metallurgy

07

D

C07D 207/06 (2006.01) A61K 31/506 (2006.01) A61P 29/00 (2006.01) C07C 209/00 (2006.01) C07D 207/20 (2006.01) C07D 213/82 (2006.01) C07D 213/89 (2006.01) C07D 239/42 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2700051

Disclosed are compounds of formula (I) which are bradykinin B1 receptor (B1R) antagonists. These compounds are useful to treat diseases or relieve adverse symptoms associated with inflammation and pain. The inven-tion encompasses novel compounds and acceptable derivatives thereof, phar-maceutical compositions and methods for prophylaxis and treatment of diseases involving inflammation and pain.

L'invention porte sur des composés représentés par la formule (I) qui sont des antagonistes du récepteur B1 de la bradykinine (B1R). Ces composés sont utiles pour traiter des maladies ou pour soulager des symptômes indésirables associés à l'inflammation et à la douleur. L'invention englobe de nouveaux composés et des dérivés acceptables de ceux-ci, des compositions pharmaceutiques et des procédés de prophylaxie et de traitement de maladies où interviennent l'inflammation et la douleur.

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