C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 49/255 (2006.01) A61K 31/12 (2006.01) A61K 31/192 (2006.01) A61K 31/195 (2006.01) A61K 31/24 (2006.01) A61P 25/28 (2006.01) C07C 49/252 (2006.01) C07C 63/66 (2006.01) C07C 225/22 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2746273
Disclosed are methods for identifying individuals suffering from a CNS disorder (including Alzheimer's Disease, ALS, behavioral disorders, and the like) that could be treated with a CNS drug with greater therapeutic efficacy and lower side effects and the compounds useful for such treatment. Also disclosed are methods for predicting the efficacy of a drug candidate for the treatment of a CNS disorder. The technology is also applicable to drug discovery for evaluation in animal models of neurodegenerative diseases.
La présente invention concerne des procédés permettant d'identifier des personnes souffrant d'un trouble du système nerveux central (comprenant la maladie d'Alzheimer, la sclérose latérale amyotrophique, les troubles de comportement, et analogues) qui peuvent être traités avec un médicament du système nerveux central avec une plus grande efficacité thérapeutique et des effets secondaires plus faibles ainsi que les composés utiles pour un tel traitement. L'invention concerne également des procédés permettant de prédire l'efficacité d'un médicament candidat pour le traitement du système nerveux central. La technologie est également applicable à la découverte de médicaments pour évaluation chez des modèles animaux de maladies neurodégénératives.
Abel Kenneth J.
Cashman John R.
Human Biomolecular Research Institute
Smart & Biggar
LandOfFree
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