Small molecule inhibition of rna/ligand binding

Details Small molecule inhibition of rna/ligand binding Small molecule inhibition of rna/ligand binding

A - Human Necessities

61

K

A61K 31/70 (2006.01) A01N 43/08 (2006.01) A61K 31/34 (2006.01) A61K 31/475 (2006.01) A61K 38/00 (2006.01) C12N 15/09 (2006.01) C12Q 1/68 (2006.01) C12Q 1/70 (2006.01) A61K 31/71 (1995.01)

Patent

CA 2147605

Disclosed is a method for the inhibition of binding of a ligand to an RNA, the inhibition being mediated by a small organ- ic molecule which binds to the RNA, thereby inhibiting ligand binding. A preferred class of small organic molecules are the 2-de- oxystreptamine (2-DOS) aminoglycosides. Disclosed herein are members of the 2-DOS class that are useful for the inhibition of binding of an RNA to a trans-activating protein.

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