Small molecule inhibitors of anti-apoptotic bcl-2 family...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 217/08 (2006.01) A61K 31/12 (2006.01) A61K 31/16 (2006.01) A61K 31/4725 (2006.01) A61K 31/496 (2006.01) A61P 35/00 (2006.01) C07C 39/16 (2006.01) C07C 49/245 (2006.01) C07C 235/42 (2006.01) C07C 317/40 (2006.01) C07D 211/16 (2006.01) C07D 217/06 (2006.01) C07D 403/04 (2006.01)

Patent

CA 2577752

The invention relates to small molecules which function as inhibitors of anti- apoptotic Bcl-2 family member proteins (e.g., Bcl-2 and Bcl-xL). The invention also relates to the use of these compounds for inducing apoptotic cell death and sensitizing cells to the induction of apoptotic cell death.

La présente invention concerne de petites qui agissent comme inhibiteurs des protéines des membres de la famille des anti-apoptose Bcl-2, et notamment les Bcl-2 et Bcl-xL. L'invention concerne également l'utilisation de ces composés pour induire la mort cellulaire programmée et pour sensibiliser les cellules à l'induction de la mort cellulaire programmée.

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