Small molecule inhibitors of hiv-1 capsid assembly

Details Small molecule inhibitors of hiv-1 capsid assembly Small molecule inhibitors of hiv-1 capsid assembly

A - Human Necessities

61

K

A61K 31/5375 (2006.01) A61K 31/135 (2006.01) A61K 31/165 (2006.01) A61K 31/4025 (2006.01) A61K 31/4164 (2006.01) A61K 31/473 (2006.01) A61K 31/51 (2006.01) A61P 31/18 (2006.01)

Patent

CA 2626549

The present invention provides novel methods of treating HIV infections employing small molecule inhibitors identified by chemical library (DIVERSet~ library). These small molecule inhibitors may specifically bind to HIV-1 capsid protein thereby interfering with capsid assembly. The small molecule inhibitors of the present invention can be potential drug targets in the treatment of HIV infection.

La présente invention a trait à de nouveaux procédés de traitement d'infections à VIH utilisant des inhibiteurs de petites molécules identifiés par la bibliothèque chimique (bibliothèque DIVERSet~). Ces inhibiteurs de petites molécules sont capables d'une liaison spécifique à la protéine capsidique de VIH-1 réalisant ainsi une interférence avec l'ensemble capside. Les inhibiteurs de petites molécules de la présente invention peuvent constituer des cibles de médicaments potentiels dans le traitement de l'infection à VIH.

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