Small molecule inhibitors of mdm2 and uses thereof

Details Small molecule inhibitors of mdm2 and uses thereof Small molecule inhibitors of mdm2 and uses thereof

C - Chemistry, Metallurgy

07

D

C07D 487/10 (2006.01) A61K 31/407 (2006.01) A61P 35/00 (2006.01) C07D 487/20 (2006.01) C07D 491/107 (2006.01)

Patent

CA 2598690

The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and/or sensitizing cells to additional agent(s).

La présente invention concerne de petites molécules qui font office d'inhibiteurs de l'interaction entre p53 et MDM2. Cette invention porte également sur l'utilisation de ces composés pour inhiber la croissance cellulaire, induire la mort cellulaire, induire l'arrêt du cycle cellulaire et/ou pour sensibiliser des cellules à un ou plusieurs agents additionnels.

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