Small molecule mimetics of erythropoietin

Details Small molecule mimetics of erythropoietin Small molecule mimetics of erythropoietin

C - Chemistry, Metallurgy

07

K

C07K 7/08 (2006.01) C07K 14/505 (2006.01) G01N 33/74 (2006.01) G06F 19/00 (2006.01)

Patent

CA 2251842

The invention features computer-assisted methods (100, 102, 104, 106, 200, 202, 204) for identifying molecules which will bind to the EPO receptor and act as an erythropoietin (EPO) mimetic. Preferred EPO mimetics identified using the method of the invention act as agonists of the EPO receptor in one or more in vitro or in vivo biological assays of EPO activity.

L'invention décrit des méthodes assistées par ordinateur (100, 102, 104, 106, 200, 202, 204) permettant d'identifier des molécules qui se fixent sur le récepteur EPO et agissent comme mimétique de l'érythropoïétine (EPO). Des mimétiques EPO préférés identifiés à l'aide de la méthode de l'invention jouent le rôle d'agonistes du récepteur EPO dans un ou plusieurs dosages biologiques in vitro ou in vivo de l'activité EPO.

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