A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/00 (2006.01) A61K 31/167 (2006.01) A61K 31/444 (2006.01) A61P 9/00 (2006.01) A61P 25/28 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 37/06 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2746054
Disclosed are methods and compositions for modulating the function of transcription factors, especially transcription factors that recruit epigenetic regulators (histone modifying enzymes) to specific DNA promoters. The targeted transcription factors include but are not limited to the myocyte enhancing factor (MEF2), the forkhead/winged helix transcription factor FOX-P3 and the transcription factor GATA3. Also disclosed are small molecule modulators of MEF2 and its associated factors that include but not limited to histone deacetylases (HDACs), p300/CBP and Cabin 1 and the therapeutic applications thereof.
L'invention porte sur des procédés et des compositions permettant de moduler la fonction de facteurs de transcription, notamment de facteurs de transcription qui recrutent des régulateurs épigénétiques (enzymes modifiant les histones) vers des promoteurs d'ADN spécifiques. Les facteurs de transcription ciblés comprennent, mais sans y être limités, le facteur stimulant les myocytes (MEF2), le facteur de transcription à tête de fourche/ailes formées dhélices (FOXP3) et le facteur de transcription GATA3. L'invention porte également sur des modulateurs à petite molécule de MEF2 et de ses facteurs associés qui comprennent, mais sans y être limités, des histones désacétylases (HDAC), p300/CBP et Cabin l et sur leurs applications thérapeutiques.
Chen Lin
Han Aidong
Jayathilaka Nimanthi
Petasis Nicos A.
Oyen Wiggs Green & Mutala Llp
University Of Southern California
LandOfFree
Small molecule modulators of epigenetic regulation and their... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Small molecule modulators of epigenetic regulation and their..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Small molecule modulators of epigenetic regulation and their... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1579730