Small-molecule modulators of trp-p8 activity

Details Small-molecule modulators of trp-p8 activity Small-molecule modulators of trp-p8 activity

C - Chemistry, Metallurgy

07

D

C07D 235/26 (2006.01) A61K 31/165 (2006.01) A61K 31/415 (2006.01) A61K 31/4184 (2006.01) A61P 35/00 (2006.01) C07C 233/60 (2006.01) C07C 233/62 (2006.01) C07C 237/04 (2006.01) C07C 237/44 (2006.01) C07D 231/40 (2006.01)

Patent

CA 2642297

Provided are small-molecule Trp-p8 modulators, including Trp-p8 agonists and Trp-p8 antagonists, and compositions comprising small-molecule Trp-p8 agonists as well as methods for identifying and characterizing novel small-molecule Trp-p8 modulators and methods for decreasing viability and/or inhibiting growth of Trp-p8 expressing cells, methods for activating Trp-p8-mediated cation influx, methods for stimulating apoptosis and/or necrosis, and related methods for the treatment of diseases, including cancers such as lung, breast, colon, and/or prostate cancers as well as other diseases, such as benign prostatic hyperplasia, that are associated with Trp-p8 expression.

L'invention concerne des modulateurs de l'activité de Trp-p8 à petites molécules, y compris les agonistes de Trp-p8 et les compositions comprenant des agonistes de Trp-p8 à petites molécules, ainsi que des procédés pour identifier et caractériser les nouveaux modulateurs de Trp-p8 à petites molécules et des procédés destinés à réduire la viabilité et/ou inhiber la croissance des cellules exprimant Trp-p8, des procédés pour activer l'influx cationique à médiation par Trp-p8, des procédés pour stimuler l'apoptose et/ou la nécrose et des procédés correspondants pour traiter des maladies comprenant des cancers tels que le cancer du poumon, du sein, du côlon et/ou de la prostate, ainsi que d'autres maladies telles que l'hyperplasie bénigne de la prostate, associées à l'expression de Trp-p8.

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