Small-molecule modulators of trp-p8 activity

Details Small-molecule modulators of trp-p8 activity Small-molecule modulators of trp-p8 activity

A - Human Necessities

61

K

A61K 31/4184 (2006.01) A61K 31/16 (2006.01) A61K 31/165 (2006.01) A61K 31/166 (2006.01) A61K 31/167 (2006.01) A61K 31/415 (2006.01) A61K 31/4155 (2006.01) A61P 13/08 (2006.01)

Patent

CA 2706102

Provided are small-molecule Trp-p8 modulators, including Trp-p8 agonists and Trp-p8 antagonists, and compositions comprising small-molecule Trp-p8 agonists as well as methods for identifying and characterizing novel small-molecule Trp-p8 modulators and methods for decreasing viability and/or inhibiting growth of Trp-p8 expressing cells, methods for activating Trp-p8-mediated cation influx, methods for stimulating apoptosis and/or necrosis, and related methods for the treatment of diseases, including cancers such as lung, breast, colon, and/or prostate cancers as well as other diseases, such as benign prostatic hyperplasia, that are associated with Trp-p8 expression.

L'invention concerne des modulateurs de l'activité de Trp-p8 à petites molécules, y compris les agonistes de Trp-p8 et les compositions comprenant des agonistes de Trp-p8 à petites molécules, ainsi que des procédés permettant d'identifier et de caractériser les nouveaux modulateurs de Trp-p8 à petites molécules et des procédés permettant de réduire la viabilité et/ou inhiber la croissance des cellules exprimant Trp-p8, des procédés permettant d'activer l'influx cationique à médiation par Trp-p8, des procédés permettant de stimuler l'apoptose et/ou la nécrose et des procédés correspondants permettant de traiter des maladies comprenant les cancers tels que le cancer du poumon, du sein, du côlon et/ou de la prostate, ainsi que d'autres maladies telles que l'hyperplasie bénigne de la prostate, associées à l'expression de Trp-p8.

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