C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A61K 9/127 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2398945
The present invention provides short antisense oligonucleotide compositions and methods for their use in the treatment of Bcl-2-associated diseases like cancer, such as follicular lymphoma (FL). The antisense oligonucleotides contain sequences that hybridize to Bcl-2 nucleic acids, the gene products of which are known to interact with the tumorigenic protein Bcl-2. The use of novel short antisense oligonucleotides, from 7 bases to 9 bases in length, is described in this invention. The invention also describes certain specific sequences which are longer than 9 bases and are 11 or 15 bases long. Used alone, or in conjunction with other antisense oligonucleotides, these antisense oligonucleotide compositions inhibit the proliferation of cancer cells.
L'invention concerne des compositions d'oligonucléotides courts anti-sens et des procédés servant à utiliser ces dernières dans le traitement de maladies associées à Bcl-2 de type cancer, telles que le lymphome folliculaire (FL). Ces oligonucléotides anti-sens contiennent des séquences s'hybridant aux acides nucléiques de Bcl-2, dont on sait que les produits génétiques exercent une interaction avec la protéine tumorigène Bcl-2. L'invention décrit la mise en application de ces nouveaux oligonucléotides courts antisens, présentant une longueur de 7 à 9 bases. Elle décrit également certaines séquences spécifiques plus longues que 9 bases et possédant 11 ou 15 bases. Utilisées seules ou combinées à d'autres oligonucléotides antisens, ces compositions inhibent la prolifération de cellules cancéreuses.
Gutierrez-Puente Yolanda
Lopez-Berestein Gabriel
Tari Ana M.
Board Of Regents The University Of Texas System
Goudreau Gage Dubuc
LandOfFree
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