C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 333/70 (2006.01) A61K 31/18 (2006.01) A61K 31/33 (2006.01) C07C 311/21 (2006.01) C07D 239/91 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07D 491/113 (2006.01)
Patent
CA 2461709
The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a hedgehog agonist, such as the compounds depicted in Figures 32 and 33. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal ptc pathway or agonizing smoothened or hedgehog activity.
L'invention concerne des procédés et des réactifs permettant de moduler la prolifération ou la différenciation cellulaire ou tissulaire. Ces procédés comprennent l'étape consistant à mettre la cellule au contact d'un agoniste Hedgehog, tels que les composés représentés sur les figures 32 et 33. Dans certains modes de réalisation, lesdits procédés et réactifs peuvent être utilisés pour corriger ou inhiber un état de croissance aberrant ou indésirable, par exemple, par production d'une action antagoniste envers une voie de signalisation ptc normale ou d'une action agoniste envers l'activité de Smoothened ou Hedgehog.
Baxter Anthony David
Boyd Edward Andrew
Frank-Kamenetsky Maria
Porter Jeffery
Price Stephen
Borden Ladner Gervais Llp
Curis Inc.
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