Small particle formation and encapsulation

Details Small particle formation and encapsulation Small particle formation and encapsulation

B - Operations, Transporting

01

J

117/45.2

B01J 13/02 (2006.01) A61K 9/16 (2006.01) A61K 9/50 (2006.01) B01J 13/10 (2006.01)

Patent

CA 1239838

ABSTRACT Process for the formation and the simultaneous encapsulation of small particles of a compound from solution which comprises: (a) dissolving said compound in a first solvent; (b) preparing a solution of encapsulating material and an electrolyte in a second solvent which is miscible with the first solvent and in which the compound to be encapsulated is more or less insoluble, in an amount which is effective, but present in an amount just insufficient to cause coacervation of the encapsulating material without interacting with it; (c) mixing the solutions from step (a) and (b) while stirring to cause the concurrent precipitation of the compound as small particles and formation of a coacervate of the encapsulating material; and (d) gelling the encapsulating material.

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