C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/06 (2006.01) A61K 38/08 (2006.01) C07K 1/10 (2006.01) C07K 7/02 (2006.01) C07K 7/08 (2006.01) C07K 7/22 (2006.01) C07K 14/575 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2089247
23305-1213 Abstract The invention relates to novel peptide and pseudopeptide amides of the formulae (1) to (6), wherein p-HOPA-D-Trp-Phe-D-Trp-Leu ?(CH2NH)Leu-NH2 (1) D-MePhe-D-Trp-Phe-D-Trp-Leu ?(CH2NH)Leu-NH2 (2) D-MePhe-D-Trp-Phe-D-Trp-Leu-MPA (3) D-Tyr-D-Trp-Phe-D-Trp-Leu ?(CH2NH)Leu-NH2 (4) D-Tyr(Et)-D-Trp-Phe-D-Trp-Leu ?(CH2NH)Leu-NH2 (5) D-MePhe-D-Trp-Tyr-D-Trp-Leu ?(CH2NH)Leu-NH2 (6) wherein p-HOPA means p-hydroxyphenylacetic acid, D-MePhe stands for D-N-methylphenylalanine, MPA represents 2-amino-3-methylpentane and ?(CH2NH) is a methyleneamino group being present instead of a peptide bond, as well as their pharmaceutically acceptable acid addition salts. The invention further relates to pharmaceutical compositions containing these compounds as well as a process for preparing the compounds of formulae (1) to (6). The compounds according to the invention are useful for inhibiting the proliferation of cells of the small-cell and epithelial-cell lung cancer.
Balogh Gabor
Bartha Laszlo
Kisfaludy Lajos
Nagy Jozsef
Nyeki Olga
Fetherstonhaugh & Co.
Richter Gedeon Vegyeszeti Gyar Rt
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