Small peptides and methods for treatment of asthma and...

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/06 (2006.01) A61K 38/07 (2006.01) A61K 39/02 (2006.01) C07K 5/00 (2006.01) C07K 5/08 (2006.01) C07K 5/083 (2006.01) C07K 5/10 (2006.01) C07K 5/103 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2309639

A pharmaceutical composition is described as an admixture of a pharmacological carrier and a peptide having the formula: f-Met-Leu-X. X is selected from the group consisting of Tyr, Tyr-Phe, Phe-Phe and Phe-Tyr. Also described are methods for inhibiting the degranulation of mast cells and for treating inflammation in a patient, for example, where the inflammation is a result of a disease selected from the group consisting of asthma, rheumatoid arthritis and anaphylaxis. In addition, methods are described for inhibiting the release of cytokines in a patient, for inhibiting the release of histamines in a patient, for inhibiting the release leukotrienes in a patient, for reducing adhesion, migration and aggregation of lymphocytes, eosinophils and neutrophils to a site of inflammation in a patient, for reducing the production of IgE antibodies at site of inflammation in a patient, and for inhibiting increased vascular permeability at site of inflammation in a patient. The methods use the described pharmaceutical composition.

L'invention concerne une composition pharmaceutique se présentant sous la forme d'un mélange d'un excipient pharmacologique et d'un peptide ayant la formule f-Met-Leu-X. X est choisit dans le groupe comprenant Tyr, Tyr-Phe, Phe-Phe et Phe-Tyr. L'invention concerne également des méthodes d'inhibition de la dégranulation des mastocytes et de traitement de l'inflammation chez un patient, par exemple, lorsque l'inflammation résulte d'une maladie figurant dans le groupe comprenant l'asthme, la polyarthrite rhumatoïde et l'anaphylaxie. L'invention concerne également des méthodes d'inhibition de la libération de cytokines chez un patient, d'inhibition de la libération d'hystamines chez un patient, d'inhibition de la libération de leucotriènes chez un patient, de réduction de l'adhésion de la migration et de l'aggrégation de lymphocytes d'éosinophiles et de neutrophiles sur un site d'inflammation chez un patient, de réduction de la production d'anticorps IgE sur un site d'inflammation chez un patient et d'inhibition de la perméabilité vasculaire accrue sur un site d'inflammation chez un patient. Les méthodes utilisent les compositions pharmaceutiques décrites.

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