A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/10 (2006.01) A61K 38/08 (2006.01) A61P 25/28 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01)
Patent
CA 2550085
A pharmaceutical composition that includes a peptide offormula Y-(X-aa)-Z. (X- aa) is generally an amino acid sequence selected from -Arg-Val-Ser-Val-Arg-Trp- , -Arg-Val-Ala-Val-Ile-, -His-Gly-Arg-Leu-Val-Phe-, -Leu-Ala-Phe-Val-Leu-Arg-, and -Thr-Leu-Phe-Leu-Ala-Arg-. And Y is generally an amino terminal modifying group selected from an amino acid, a N-acylated amino acid, a peptide, a N- acylated peptide, and hydrogen. And Z- is carboxyl-terminal modifying group selected from hydrogen, an amino acid, a C-amidated amino acid, a peptide, a C- amidated peptide, or an amide or hydroxyl group such as an alkyl amide, an aryl amide, or an alcohol. A composition of matter that includes at least one of the peptide sequences -Arg-Val-Ala-Val-Ile-, -Leu-Ala-Phe-Val-Leu-Arg-, - Thr-Leu-Phe-Leu-Ala-Arg-, -Arg~Val-Ser-Val-Arg-Trp-, -His-Gly-Arg-Leu-Val-Phe- . Preferably at least one amino acid of the peptide sequence is a D- amino acid.
La présente invention a trait à une composition pharmaceutique comportant un peptide de formule Y-(X-aa)-Z, dans laquelle : (X-aa) est généralement une séquence d'acides aminés choisie parmi Arg-Val-Ser-Val-Arg-Trp-, -Arg-Val-Ala-Val-Ile-, -His-Gly-Arg-Leu-Val-Phe-, -Leu-Ala-Phe-Val-Leu-Arg-, et -Thr-Leu-Phe-Leu-Ala-Arg- ; et Y est généralement un groupe modificateur de N-terminal choisi parmi un acide aminé, un acide aminé d'acylation N, un peptide, un peptide d'acylation N, et hydrogène ; et Z est un groupe modificateur de C-terminal choisi parmi hydrogène, un acide aminé, un acide aminé d'amidation C, un peptide, un peptide d'amidation C, ou un groupe amide ou hydroxyle tels qu'un alkylamide, un arylamide, ou un alcool. L'invention a également trait à une composition de matière comportant au moins un des séquences peptidiques -Arg-Val-Ala-Val-Ile-, -Leu-Ala-Phe-Val-Leu-Arg-, -Thr-Leu-Phe-Leu-Ala-Arg-, -Arg-Val-Ser-Val-Arg-Trp-, -His-Gly-Arg-Leu-Val-Phe-. De préférence, au moins un acide aminé de la séquence peptidique est un acide aminé D.
Castillo Gerardo M.
Lake Thomas P.
Nguyen Beth P.
Sanders Virginia J.
Snow Alan D.
Proteotech Inc.
Smart & Biggar
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