C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
167/44, 530/7.06
C07K 7/06 (2006.01) A61K 39/21 (2006.01) A61K 39/42 (2006.01) C07K 14/16 (2006.01) C07K 14/73 (2006.01) C07K 16/10 (2006.01) C07K 17/02 (2006.01) G01N 33/53 (2006.01) G01N 33/569 (2006.01) A61K 38/00 (2006.01)
Patent
CA 1341066
Short peptide of the formula: R a-Ser-Thr-Thr-Thr-Asn-Tyr-R b ~~(I) where R a represents an amino terminal residue Ala- or D-Ala and R b represents a carboxy terminal residue -Thr or -Thr amide or a derivative thereof with an additional Cys- residue at one or both of the amino and carboxy terminals, or a peptide of formula (II): R1-R2-R3-R4-R5 (II) where R1 is an amino terminal residue Thr-, Ser-, Asn-,Leu-,Ile-,Arg- or Glu- R2 is Thr, Ser or Asp R3 is Thr, Ser, Asn, Arg, Gln, Lys or Trp R4 is Tyr and R5 is a carboxy terminal amnio group or a derivative thereof with a corresponding D- amino acid as the amino terminal residue, and/or a corresponding amide derivative at the carboxy terminal residue and/or additionally a Cys- residue at one or both of the amino and carboxy terminals, or a physiologically acceptable salt thereof. Such peptides bind to T4 receptors are useful in preventing viral infectivity by viruses which bind to the T4 receptors. These peptides are believed to act as completitive blocking agents.
538202
Farrar William L.
Pert Candace B.
Ruff Michael R.
Borden Ladner Gervais Llp
The United States Of America As Represented By The Secretary U.s
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