Small streptococcus pyogenes antigens and their use

Details Small streptococcus pyogenes antigens and their use Small streptococcus pyogenes antigens and their use

C - Chemistry, Metallurgy

07

K

C07K 14/315 (2006.01) A61K 39/09 (2006.01) C07K 16/12 (2006.01) C12N 5/16 (2006.01) C12N 15/31 (2006.01) C12P 21/08 (2006.01) G01N 33/569 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2656771

The present invention relates to a peptide consisting of one antigen of Streptococcus pyogenes (S. pyogenes) of any of the SEQ ID NOS: 1 to 7 or a functional active variant thereof, optionally further consisting of additional amino acid residue(s); a nucleic acid coding for the same; a pharmaceutical composition, especially a vaccine, comprising said peptide or said nucleic acid; an antibody or functional active fragment thereof specifically binding to the antigen; a hybridoma cell line which produces said antibody; a method for producing said antibody; a pharmaceutical composition comprising said antibody; the use of said peptide or said nucleic acid for the manufacture of a medicament for the immunization or treatment of a subject; the use of said antibody or functional fragment thereof for the manufacture of a medicament for the treatment of an infection; a method of diagnosing a S. pyogenes infection; a method for identifying a ligand capable of binding to said peptide; and the use of said peptide for the isolation and/or purification and/or identification of an interaction partner of the peptide.

La présente invention concerne un peptide consistant en un antigène de Streptococcus pyogenes (S. pyogenes) de l'un des SEQ ID NOS : 1 à 7 ou un variant actif fonctionnel de celui-ci, facultativement consistant en plus en un ou des résidus d'acides aminés additionnels ; un acide nucléique codant pour ledit peptide ; une composition pharmaceutique, notamment un vaccin, comprenant ledit peptide ou ledit acide nucléique ; un anticorps ou fragment actif fonctionnel de celui-ci se liant de façon spécifique à l'antigène ; une ligne de cellules d'hybridome qui produit ledit anticorps ; un procédé de fabrication dudit anticorps ; une composition pharmaceutique comprenant ledit anticorps ; l'utilisation dudit peptide ou dudit acide nucléique pour la fabrication d'un médicament pour l'immunisation ou le traitement d'un sujet ; l'utilisation dudit anticorps ou fragment fonctionnel de celui-ci pour la fabrication d'un médicament pour le traitement d'une infection ; un procédé de diagnostic d'une infection par S. pyogenes ; un procédé pour identifier un ligand capable de se lier audit peptide ; et l'utilisation dudit peptide pour l'isolement et/ou la purification et/ou l'identification d'un partenaire d'interaction du peptide.

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